Sajad Abolfazli, Alexandra E. Butler, Prashant Kesharwani, Amirhossein Sahebkar

The Journal of Pharmacy and Pharmacology, 2024-08-24

Lipotoxicity is defined as a prolonged metabolic imbalance of lipids that results in ectopic fat distribution in peripheral organs such…

Ziqiang Lin, Suo Wang, Yu Cao, Jialing Lin, Ailing Sun, Wei Huang, Jun Zhou, Qingxiong Hong

Neuropharmacology, 2024-08-22

Diabetic peripheral neuropathy (DPN) is a common nerve-damaging complication of diabetes mellitus. Effective treatments are needed to alleviate and reverse…

Xiao Qin, Peng Wang, Haiyue Liang, Wentao Si

BMC pharmacology & toxicology, 2024-08-21

BACKGROUND: Non-small cell lung cancer (NSCLC) is associated with intracellular copper accumulation. Antioxidant 1 (ATOX1) is a copper chaperone. This…

Hanie Hosseini, Mohammad Bagherniya, Amirhossein Sahebkar, Bijan Iraj, Muhammed Majeed, Gholamreza Askari

Phytotherapy research: PTR, 2024-08-20

Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with insulin resistance and ensuing dysglycemia, dyslipidemia, and inflammation. Owing…

Habibeh Mashayekhi-Sardoo, Samaneh Sepahi, Adel Ghorani-Azam, Hedyeh Askarpour, Thomas P. Johnston, Amirhossein Sahebkar

International Journal of Environmental Health Research, 2024-08-19

Microplastics and nanoplastics (MNPs) are present in urban dust and the aquatic environments of industrialized cities. MNPs in the human…

Seila Tolentino, Camila O. Cardoso, Mylene M. Monteiro, Stephania F. Taveira, Tais Gratieri, Marcilio Cunha-Filho, Eliete N. S. Guerra, Guilherme M. Gelfuso

International Journal of Biological Macromolecules, 2024-08-19

This study aimed to develop mucoadhesive chitosan-based films capable of enhancing the curcumin penetration into the oral mucosa to treat…

Natalia V. Chalupczak, Peter A. Lio

Archives of Dermatological Research, 2024-08-17

Despite recent advancements in psoriasis treatment, challenges in management persist. Recently, there has been a rising interest amongst patients in…

Hua Ye, Ze-Qin Li, Jia-Ming Yang, Yi Long, Yan-Biao Zhong, Yi Wu, Mao-Yuan Wang

European Journal of Pharmacology, 2024-08-16

BACKGROUND: Knee osteoarthritis (KOA) is a very common musculoskeletal disorder, and patients with KOA often exhibit significant quadriceps femoris muscle…

Peng-Hui Yang, Ya-Nan Wei, Bi-Juan Xiao, Si-Yi Li, Xin-Long Li, Liang-Jun Yang, Hua-Feng Pan, Geng-Xin Chen

World Journal of Gastrointestinal Oncology, 2024-08-15

BACKGROUND: Curcumin originates from the natural herb turmeric, and its antitumor effects have been known about for a long time.…

Yongli Xie, Xuexia Li, Qingqing Shi, Linfeng Le, Chao Wang, Hao Xu, Guoli Wu, Xiubo Du, Zetao Chen

Brain Research, 2024-08-15

Given the complexity and heterogeneity of Alzheimer's disease (AD) pathology, targeted monotherapy drugs may not be effective. Therefore, synergistic combination…